What is the DISCO study all about?

DISCO stands for Doxycycline as an Intervention for bacterial STI ChemOprophylaxis. It’s a Canadian study, aiming to enroll 447 gay, bisexual and other men who have sex with men (gbMSM), including both cisgender and transgender gbMSM, and transgender women. Participants will be enrolled randomly into one of three study arms: (1) the doxycycline pre-exposure prophylaxis (PrEP) arm, where they will take a doxycycline pill daily; (2) the doxycycline post-exposure prophylaxis (PEP) arm, where they will take two doxycycline pills within 72 hours of a sexual encounter, to a maximum of six pills per week; or, (3) the ‘standard of care’ arm, where participants will not take any doxycycline, but rather will receive routine STI care.