Doctor and researcher look at a computer screen


Doxycycline as an Intervention for bacterial STI ChemOprophylaxis (or DISCO for short) is a new Canada-wide clinical study that aims to explore the use of doxycycline-based STI pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) for the prevention of STIs in gay, bisexual and other men who have sex with men, transgender women and other gender-diverse people. It’s the first methodologically rigorous, prospective multicentre, open-label randomized controlled trial of its kind.

Beyond exploring efficacy, DISCO will also provide insight into the acceptability, tolerability and safety of therapy with doxycycline. We aim to provide health care providers one additional tool to address the burden of STIs in populations with an increased likelihood of infection.